San Domenico Maggiore, built about 1300, is among the most beautiful and interesting churches in Naples, filled with Early Renaissance work. 

The ornate paneled ceiling leads your eyes directly to the high altar by Cosimo Fanzago. 

Each of its 24-sided chapels contains something of interest, especially the Chapel of San Michele Arcangelo a Morfisa at the end of the right nave, which incorporates a 10th-century church.

 In the Cappellone Crocifisso are a 13th-century Crucification and the 15th-century Burial of Christ.