The short Via Dante leads south from Piazza De Ferrari to Piazza Dante, where you'll see the two well-preserved towers of Porta Soprana, a gate in the city walls, built in 1155.

 Christopher Columbus spent his childhood in the much-restored stone house next to the beautiful little cloister of Sant'Andrea. 

There's not much to see in the museum inside, but the combination of the house, gate, and cloister make this short detour worthwhile as you are sightseeing in Genoa.