This palace was built by the powerful noble Chiaramonte family from Agrigento in the 14th century, when the family reached the height of its power.

 Work commenced in 1307 and continued until 1380, but the second floor was never completed. In 1396, Andrea Chiaramonte was publicly beheaded in front of his palace because he had rebelled against the king.

The palace served as the viceroy's residence between 1468 and 1517, as the seat of the Inquisition around 1600, and as a courthouse from 1799. The massive block building with four wings around a square inner courtyard is now a museum.