The Kunstmuseum, enhanced by the added exhibition space of a 2015 wing, is considered the finest collection of paintings in Switzerland, representing both old masters and modern art.

 On the first floor are the old masters and a collection of French and Dutch paintings. Outstanding among these are the 15th-century Heilsspiegelaltar (Mirror of Salvation Altar) by Konrad Witz, 16th-century portraits by Holbein the Younger, Crucifixion by Mathias Grünewald, and Rembrandt's David with Goliath's Head from 1627. 

The second floor houses an outstanding collection of 19th- and 20th-century Impressionists, Expressionists, and Surrealists.