To the west of Waisenhausplatz, on the Hodlerstrasse, is the famed Kunstmuseum (Museum of Art). This massive and impressive art museum is home to more than 51,000 paintings, sculptures, drawings, prints, photographs, and films. It is the oldest art museum in Switzerland, built in 1879, and holds an international reputation.

The collection comprises art from the Italian Trecento (Duccio, Fra Angelico); Swiss art since the 15th century (Niklaus Manuel, Albert Anker, Ferdinand Hodler, Cuno Amiet); and international painting from the 19th and early 20th centuries (Impressionism, Cubism, Expressionism, Blaue Reiter, Surrealism); with particular focus on Paul Klee, Wassily Kandinsky, and Pablo Picasso.