The Museum of Science and Industry (MOSI) is on the site of the world's oldest railroad station. Its 12 galleries include the Power Hall, with water and steam-driven machines from the golden age of the textile industry, as well as vintage made-in-Manchester cars, including a rare 1904 Rolls Royce.

 The history of the city from Roman times through the Industrial Revolution to the present day is documented in the Station Building. The Air and Space Gallery is another must-see and is home to numerous historic aircraft, including a replica of Triplane 1 by A. V. Roe, the first British plane to successfully fly.