This exceptional museum is housed in the 16th-century Hospital de Santa Cruz, an elegant building with an exquisite Plateresque facade. The Santa Cruz Museum includes three collections: Fine Arts, Decorative Arts, and Archaeology. 

In the Fine Arts collection, the paintings of the 16th and 17th century School of Toledo are the main attraction, especially the works by El Greco and Luis Tristán, a student of El Greco. The Assumption of the Virgin by El Greco is a masterpiece created in the artist's later years. 

Other highlights are the Christ in Chains by Morales and the Crucifixion by Goya. The retablo dedicated to the Virgin by Alonso Berruguete is another valuable piece.

 The Decorative Arts section includes Flemish tapestries of the 15th and 16th centuries and a tapestry illustrating the signs of the Zodiac as well as local artisan crafts. The Archeology section contains prehistoric, Roman, Visigothic antiquities, and exhibits of Moorish and Mudéjar decorative objects and ceramics